Explore the Facts:
Major Depression & Suicide
What are the Causes of Major Depression?
There is no single cause of major depression. Psychological, biological, and environmental
factors may all contribute to its development. Whatever the specific causes of depression,
scientific research has firmly established that major depression is a biological brain
disorder.
Norepinephrine, serotonin, and dopamine are three neurotransmitters (chemical messengers
that transmit electrical signals between brain cells) thought to be involved with major
depression. Scientists believe that if there is a chemical imbalance in these neurotransmitters,
then clinical states of depression result. Antidepressant medications work by increasing the
availability of neurotransmitters or by changing the sensitivity of the receptors for these
chemical messengers.
Scientists have also found evidence of a genetic predisposition to major depression. There
is an increased risk for developing depression when there is a family history of the illness.
Not everyone with a genetic predisposition develops depression, but some people probably have
a biological make-up that leaves them particularly vulnerable to developing depression. Life
events, such as the death of a loved one, a major loss or change, chronic stress, and alcohol
and drug abuse, may trigger episodes of depression. Some illnesses such as heart disease and
cancer and some medications may also trigger depressive episodes. It is also important to note
that many depressive episodes occur spontaneously and are not triggered by a life crisis,
physical illness, or other risks.
NEXT: How is Major Depression
Treated? |
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DEPRESSION
& SUICIDE LINKS
What is Major Depression?
What are the Symptoms of Major Depression?
What are the Causes of Major Depression?
How is Major Depression Treated?
Risk Factors for Suicide
Warning Signs of Suicide
ADDITIONAL
RESOURCES:
American Foundation for Suicide Prevention |
